Proton Radiation Therapy for Gliomas


In this research study the investigators are looking at a type of radiation called proton radiation. Proton radiation has been shown to deliver virtually no radiation beyond the area of the tumor, sparing surrounding normal tissue from exposure. This may reduce side effects that patients would normally experience with conventional radiation therapy. In this research study the investigators are looking to determine if proton radiation with a reduced field size will be as effective in controlling tumor growth as photon therapy, while reducing the treatment-related side effects observed in patients with brain tumors.

Study Start Date

May 2011

Estimated Completion Date

May 2019


  • Radiation: Proton radiation


  • Internal Medicine: Hematology/Oncology,Radiology/Diagnostics
  • Oncology: Neurologic Oncology,Pharmacology/Therapy
  • Radiology: Radiotherapy (XRT)

MeSH Terms

  • Astrocytoma
  • Glioma
  • Oligodendroglioma
  • Radiotherapy

Study ID

Massachusetts General Hospital -- 10-439



Trial ID


Study Type


Trial Phase

Phase 2

Enrollment Quota



Massachusetts General Hospital

Inclusion Criteria

  • Histologically confirmed low-grade gliomas
  • Subject must be indicated for radiation therapy
  • Life expectancy greater than 5 years
  • Willing to participate in rigorous neurocognitive evaluations at baseline and serially following treatment
  • Able to speak and comprehend English
  • Recovered from adverse events due to agents administered more than 4 weeks before entering study
  • Able to undergo MRI scans

Exclusion Criteria

  • Prior cranial radiation therapy
  • Chemotherapy within 4 weeks prior to entering study
  • Pregnant or breastfeeding
  • Known brain metastases
  • Baseline neurocognitive or emotional disorders
  • Uncontrolled intercurrent illness
  • History of a different malignancy unless disease-free for at least 5 years
  • HIV positive on antiretroviral therapy




18 Years and older

Accepts Healthy Volunteers


Study Locations and Contact Information (1)

Study Location Distance Name Phone Email
Massachusetts General Hospital - Boston, Massachusetts 2.8 miles None None None provides clinical trial listings in an easy to view format. All clinical trial information is pulled directly from This website does not guarantee acceptance into any clinical trial, and is not responsible for adverse events that may be incurred from a clinical trial.