Genes and Environment in Multiple Sclerosis

Description

The purpose of the research study is to identify the genetic, environmental and immune profiles that may increase a person's risk of developing multiple sclerosis (MS). While MS is not a disease caused by a single variation in genetic material (DNA), a single environmental factor, or a single malfunction in immune cells, there are genetic alterations, environmental exposures and immunologic factors that make the development of MS more likely. Obtaining information about who is at risk for MS will be beneficial in the future if the investigators can identify effective ways to prevent or slow down the progression of this disease.

Study Start Date

March 2010

Estimated Completion Date

March 2020

Interventions

No interventions cited

Specialties

  • Internal Medicine: Basic Science/Genetics,Neurology
  • Neurology: Basic Science/Genetics,Demyelinating Disorders
  • Physician Assistant: Neurology

MeSH Terms

  • Multiple Sclerosis
  • Sclerosis

Study ID

Brigham and Women's Hospital -- 2009p002561

Status

Unknown

Trial ID

NCT01353547

Study Type

Observational

Trial Phase

N/A

Enrollment Quota

5000

Sponsor

Brigham and Women's Hospital

Inclusion Criteria

  • First Degree Relatives of Patients with MS, or
  • Patients who have received anti-TNFa therapy as treatment for inflammatory diseases other than MS such as Crohn's disease, psoriasis and rheumatoid arthritis, or
  • Patients that have been referred for an evaluation of first presentation of neurologic symptoms but do not have a diagnosis of MS
  • Live in the United States

Exclusion Criteria

  • Does not match any of the inclusion criteria

Gender

Both

Ages

18 Years to 50 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Study Locations and Contact Information (1)

Study Location Distance Name Phone Email
Emily Owen - Boston, Massachusetts 2.6 miles None None None

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