Selecting a Favorable KIR Donor in Unrelated HCT for AML

Description

Donors with favorable KIR B haplotype gene content have yielded reduced relapse risk and improved leukemia free survival (LFS) in retrospective analyses of unrelated donor (URD) hematopoietic cell transplantation (HCT) for acute myelogenous leukemia (AML). Specifically, donors with more KIR B gene content and those who are homozygous for the centromeric (Cen) B haplotype genes (as opposed to the telomeric (Tel) genes confer the most protective effect. This study proposes to prospectively test and validate the utility and effectiveness of further informing URD identification and selection by KIR genotyping as a supplement to HLA matching and the other variables known or suspected to indicate the best URD for a patient. Hypotheses: 1. Favorable KIR donors will improve protection against relapse and improve leukemia free survival (LFS) after URD HCT for AML. 2. Directed study procedures for rapid KIR genotyping and reporting to searching Transplant Centers (TC) can inform donor search and selection without delay in donor availability for HCT.

Study Start Date

June 2011

Estimated Completion Date

July 2016

Interventions

  • Biological: KIR genotype
  • Biological: Unrelated donor transplant

Specialties

  • Internal Medicine: Hematology/Oncology
  • Oncology: Leukemia/Lymphoma
  • Physician Assistant: Hematology/Oncology

MeSH Terms

  • AML
  • KIR genotype
  • Leukemia
  • Myeloid

Study ID

Masonic Cancer Center, University of Minnesota -- 2010LSUC043

Status

Unknown

Trial ID

NCT01288222

Study Type

Interventional

Trial Phase

N/A

Enrollment Quota

800

Sponsor

Masonic Cancer Center, University of Minnesota

Inclusion Criteria

  • Patient with acute myeloid leukemia (AML) undergoing screening for potential URD HCT
  • Potential URD undergoing screening to provide a HCT graft to a patient with acute myeloid leukemia (AML) at a participating institution
  • Provides written consent

Gender

Both

Ages

N/A

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Study Locations and Contact Information (28)

Study Location Distance Name Phone Email
Hackensack University Medical Center - Hackensack, New Jersey 47.6 miles None None None
New York Presbyterian Weill Cornell Medical Center - New York City, New York 48.5 miles None None None
University of Pennsylvania - Philadelphia, Pennsylvania 134.5 miles David Porter MD 215-662-5858 david.porter@uphs.upenn.edu
University of Pennsylvania - Philadelphia, Pennsylvania 134.5 miles None None None
Roswell Park Cancer Institute - Buffalo, New York 310.8 miles None None None
Roswell Park Cancer Institute - Buffalo, New York 310.8 miles Maureen Ross MD 716-845-2300 maureen.ross@roswellpark.org
Cleveland Clinic - Cleveland, Ohio 435.4 miles Ronald Sobecks MD 216-445-4626 sobeckr@ccf.org
Cleveland Clinic - Cleveland, Ohio 435.4 miles None None None
Ohio State University Comprehensive Cancer Center - Columbus, Ohio 520.3 miles None None None
Indiana University Simon Cancer Center - Indianapolis, Indiana 686.4 miles Sherif Farag MD 317-274-0843 ssfarag@iupui.edu
Indiana University Simon Cancer Center - Indianapolis, Indiana 686.4 miles None None None
University of Chicago Medical Center Cancer Center - Chicago, Illinois 744.7 miles Koen van Besien MD 773-702-6149 kvbesien@medicine.bsd.uchicago.edu
University of Chicago Medical Center Cancer Center - Chicago, Illinois 744.7 miles None None None
Emory University - Atlanta, Georgia 795.6 miles None None None
Washington University School of Medicine - St. Louis, Missouri 919.8 miles None None None
Washington University School of Medicine - St. Louis, Missouri 919.8 miles Peter Westervelt MD 314-454-8323 pwesterv@im.wustl.edu
Mayo Clinic Cancer Center - Rochester, Minnesota 997.5 miles Mark Litzow MD 507-284-2511 litzow.mark@mayo.edu
Mayo Clinic Cancer Center - Rochester, Minnesota 997.5 miles None None None
Masonic Cancer Center University of Minnesota - Minneapolis, Minnesota 1,040.9 miles Daniel Weisdorf MD 612-624-0123 weisd001@umn.edu
Masonic Cancer Center University of Minnesota - Minneapolis, Minnesota 1,040.9 miles None None None
Kansas University Cancer Center - Kansas City, Kansas 1,138.2 miles None None None
Baylor Sammons Cancer Center - Dallas, Texas 1,420.1 miles None None None
MD Anderson Cancer Center - Houston, Texas 1,475.7 miles None None None
Methodist Healthcare System of San Antonio - San Antonio, Texas 1,635.9 miles None None None
Colorado Blood Cancer Institute - Denver, Colorado 1,665.3 miles None None None
Mayo Clinic Scottsdale - Scottsdale, Arizona 2,167.5 miles None None None
Fred Hutchinson Cancer Research Center - Seattle, Washington 2,427.3 miles None None None
Fred Hutchinson Cancer Research Center - Seattle, Washington 2,427.3 miles Ann E Woolfrey MD 206-667-4324 awoolfre@fhcrc.org

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