The Genetics of Respiratory Failure in Bronchiolitis

Description

Bronchiolitis is a potentially severe infection of the airway in infants and children, and among the most frequent diagnoses leading to pediatric intensive care unit admission in infants. This acute infection is caused by an array of viruses, but respiratory syncytial virus (RSV) is the most frequently implicated. The majority of infants hospitalized with bronchiolitis are previously healthy, and half of infants intubated and mechanically ventilated for respiratory failure due to RSV bronchiolitis have no previously identified risk factors. It is likely, therefore, that other factors, particularly genetic heterogeneity of the host, contribute to disease severity. However, no previous study has investigated the association of genetic variants with respiratory failure in children with bronchiolitis. Several categories of candidate genes have emerged as potentially important in the pathogenesis of the disease. Specifically, genetic polymorphisms of surfactants, pattern recognition receptors, receptor adhesion molecules, and cytokines have been examined. The aim is to evaluate these polymorphisms to determine their association with respiratory failure in a cohort of more severely ill children with bronchiolitis.

Study Start Date

November 2010

Estimated Completion Date

October 2018

Interventions

No interventions cited

Specialties

  • Pediatrics: Basic Science/Genetics,Pediatric Pulmonology,Peds Infectious Disease
  • Pulmonology: Basic Science/Genetics,Peds Pulmonology,Pulm/Thoracic Infections

MeSH Terms

  • Bronchiolitis
  • Bronchiolitis, Viral

Study ID

Connecticut Children's Medical Center -- 10-097

Status

Unknown

Trial ID

NCT01271491

Study Type

Observational

Trial Phase

N/A

Enrollment Quota

146

Sponsor

Connecticut Children's Medical Center

Inclusion Criteria, cases:
  • admission to the ICU with a primary diagnosis of bronchiolitis
  • endotracheally intubated and mechanically ventilated with respiratory failure due to bronchiolitis
  • age less than 2 years Exclusion Criteria, cases:
  • pre-existing chronic disease including: 1. bronchopulmonary dysplasia 2. congenital heart disease 3. immune deficiency
  • requiring an additional venopuncture for blood collection for genotyping Inclusion Criteria, controls:
  • admission to the hospital with a primary diagnosis of bronchiolitis
  • age less than 2 years Exclusion Criteria, controls:
  • pre-existing chronic disease including: 1. bronchopulmonary dysplasia 2. congenital heart disease 3. immune deficiency
  • requiring an additional venopuncture for blood collection for genotyping
  • requiring non-invasive positive pressure ventilation or high flow nasal cannula
  • requiring intubation and mechanical ventilation during the hospitalization
  • Gender

    Both

    Ages

    2 Years and younger

    Accepts Healthy Volunteers

    No

    Study Locations and Contact Information (2)

    Study Location Distance Name Phone Email
    Connecticut Childrens Medical Center - Hartford, Connecticut 46.8 miles None None None
    Connecticut Childrens Medical Center - Hartford, Connecticut 46.8 miles Christopher L Carroll MD MS 860-545-9805 ccarrol@ccmckids.org

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