Assessing Response to Albuterol in Bronchiolitis

Description

Bronchiolitis is a significant cause of morbidity and hospitalizations in children, accounting for more than 125,000 hospitalized children per year in the United States. Although treatment is largely supportive, bronchodilator medications such as albuterol are frequently used due to increased pulmonary resistance in this population.2-4 However, despite four decades of clinical trials, the efficacy of albuterol in the treatment of bronchiolitis has yet to be proven. This inconsistency is due in part to the lack of sufficiently sensitive methods for the evaluation of lung function and thus the response to albuterol in infants. Because of the difficulties in evaluating the response to therapy, healthcare providers are forced to rely on their physical examination skills or a clinical scoring system, both of which are highly subjective in this population. The investigators propose to conduct a prospective observational study of healthcare providers to determine the accuracy of clinical assessment as compared to that of pulmonary mechanics in a population of children intubated and mechanically ventilated for bronchiolitis.

Study Start Date

November 2010

Estimated Completion Date

April 2018

Interventions

No interventions cited

Specialties

  • Pediatrics: Pediatric Pulmonology
  • Pulmonology: Clinical Pharmacology,Peds Pulmonology,Restrictive Lung Dz
  • Pharmacy: Drug Trials
  • Hospitalist:

MeSH Terms

  • Albuterol
  • Bronchiolitis

Study ID

Connecticut Children's Medical Center -- 10-095

Status

Unknown

Trial ID

NCT01238445

Study Type

Observational

Trial Phase

N/A

Enrollment Quota

25

Sponsor

Connecticut Children's Medical Center

Inclusion Criteria

  • Hospitalization with a primary admission diagnosis of bronchiolitis
  • Age between birth and 2 years
  • Intubated with < 1 cm H2O leak around endotracheal tube
  • Receiving inhaled albuterol therapy

Exclusion Criteria

  • Not meeting inclusion criteria

Gender

Both

Ages

2 Years and younger

Accepts Healthy Volunteers

No

Study Locations and Contact Information (2)

Study Location Distance Name Phone Email
Connecticut Childrens Medical Center - Hartford, Connecticut 46.8 miles None None None
Connecticut Childrens Medical Center - Hartford, Connecticut 46.8 miles Christopher L Carroll MD MS 860-545-9805 ccarrol@ccmckids.org

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