The Genetics of Severe Asthma in Children

Description

Near fatal asthma exacerbations are one of the most common causes of critical illness in children, accounting for approximately ten thousand intensive care unit (ICU) admissions per year in the United States. Even children with intermittent or mild baseline asthma can develop these severe exacerbations; however, there are few studies evaluating the risk factors associated with the development of near fatal asthma exacerbations in children. Inhaled ß2-adrenergic receptor (ADRß2) agonist therapy is the foundation of therapy for acute asthma and genetic variations of this receptor have been shown to affect response to ADRß2 agonist therapy in this population. The investigators hypothesis is that a child's ADRß2 genotype is associated with the development of a near fatal asthma exacerbation.

Study Start Date

October 2009

Estimated Completion Date

April 2018

Interventions

No interventions cited

Specialties

  • Pediatrics: Pediatric Pulmonology,Peds Allergy/Immunology
  • Pulmonology: Asthma/Atopy
  • Allergy/Immunology: Allergy/Anaphylaxis,Peds Allergy/Immunology

MeSH Terms

  • Asthma
  • Fatal asthma
  • Genetics

Study ID

Connecticut Children's Medical Center -- 08-103

Status

Unknown

Trial ID

NCT01238432

Study Type

Observational

Trial Phase

N/A

Enrollment Quota

558

Sponsor

Connecticut Children's Medical Center

Inclusion Criteria, inpatient asthmatics:
  • Admission to study institution with a primary admission diagnosis of asthma exacerbation
  • Age between 4 and 18 years Exclusion Criteria, inpatient asthmatics:
  • Pre-existing chronic disease (other than asthma), including: i. bronchopulmonary dysplasia ii. bronchomalacia iii. tracheomalacia iv. laryngomalacia v. vocal cord dysfunction vi. chronic restrictive lung disease vii. recurrent aspiration pneumonia viii. impaired mucous clearance ix. congenital heart disease x. pulmonary hypertension Inclusion Criteria, outpatient asthmatics:
  • Diagnosis of asthma
  • Age between 4 and 18 years Exclusion Criteria, outpatient asthmatics:
  • Previous admission to the hospital for a near fatal asthma exacerbation
  • Pre-existing chronic disease (other than asthma) including i. bronchopulmonary dysplasia ii. bronchomalacia iii. tracheomalacia iv. laryngomalacia v. vocal cord dysfunction vi. chronic restrictive lung disease vii. recurrent aspiration pneumonia viii. impaired mucous clearance ix. congenital heart disease x. pulmonary hypertension Inclusion Criteria, healthy controls:
  • Age between 4 and 18 years Exclusion Criteria, healthy controls:
  • Pre-existing chronic disease including: i. asthma ii. bronchopulmonary dysplasia iii. bronchomalacia iv. tracheomalacia v. laryngomalacia vi. vocal cord dysfunction vii. chronic restrictive lung disease viii. recurrent aspiration pneumonia ix. impaired mucous clearance x. congenital heart disease xi. pulmonary hypertension
  • Gender

    Both

    Ages

    4 Years to 18 Years

    Accepts Healthy Volunteers

    Accepts Healthy Volunteers

    Study Locations and Contact Information (1)

    Study Location Distance Name Phone Email
    Connecticut Childrens Medical Center - Hartford, Connecticut 48.4 miles None None None

    ClinicalTrialsLocator.com provides clinical trial listings in an easy to view format. All clinical trial information is pulled directly from ClinicalTrials.gov. This website does not guarantee acceptance into any clinical trial, and is not responsible for adverse events that may be incurred from a clinical trial.