In-Room PET in Proton Radiation Therapy


The investigational part of this study is using a mobile PET scanner called NeuroPET to take images of the participants tumor while they are receiving proton radiation treatment. This allows the participant to be treated and imaged in the same bed. The information obtained may improve the accuracy of treatment and may help to minimize the dose delivered unnecessarily to healthy tissue.

Study Start Date

October 2010

Estimated Completion Date

December 2016


  • Procedure: PET scan


  • Internal Medicine: Hematology/Oncology,Neurology,Radiology/Diagnostics
  • Neurology: Neurologic Oncology,Neuroradiology
  • Oncology: Head and Neck,Pharmacology/Therapy
  • Radiology: CT/SPECT/PET,Radiotherapy (XRT)

MeSH Terms

  • Brain Neoplasms
  • Head and Neck Neoplasms
  • PET scan
  • Skull Base Neoplasms

Study ID

Massachusetts General Hospital -- 10-241



Trial ID


Study Type


Trial Phase

Phase 0

Enrollment Quota



Massachusetts General Hospital

Inclusion Criteria

  • Adult subjects with brain, head and neck, and skull base tumors receiving external beam proton radiotherapy at the Francis H. Burr Proton Therapy Center at MGH
  • Age 18 or over
  • ECOG Performance status 0, 1 or 2
  • Subjects must have internal CT markers implanted on the skull as part of their radiation treatment planning

Exclusion Criteria

  • Uncontrolled intercurrent illness that, in the opinion of the investigator, would limit the participant's compliance with study requirements.




18 Years and older

Accepts Healthy Volunteers


Study Locations and Contact Information (1)

Study Location Distance Name Phone Email
Massachusetts General Hospital - Boston, Massachusetts 2.8 miles None None None provides clinical trial listings in an easy to view format. All clinical trial information is pulled directly from This website does not guarantee acceptance into any clinical trial, and is not responsible for adverse events that may be incurred from a clinical trial.