Melodic-Intonation-Therapy and Speech-Repetition-Therapy for Patients With Non-fluent Aphasia

Description

We are doing this clinical trial in order to evaluate two different treatments for non-fluent aphasia: Melodic Intonation Therapy (MIT) and Speech Repetition Therapy (SRT). MIT uses a simple form of singing, while SRT uses intensive repetition of a set of words and phrases. We want to see which intensive form of treatment is more effective in leading to an improvement in speech output compared to a no-therapy control period, and whether either treatment can cause changes in brain activity during speaking and changes in brain structure. We will use a technique known as functional Magnetic Resonance Imaging (fMRI) to measure blood flow changes in the brain and structural MRI that assess brain anatomy and connections between brain regions. We will use fMRI to assess brain activity while a patient speaks, sings, and hums. We will assess changes in brain activity and in brain structure by comparing scans done prior to treatment to scans obtained after treatment and we will also examine changes between treatment groups. We will correlate changes in brain activity and brain structure with changes in language test scores.

Study Start Date

February 2008

Estimated Completion Date

December 2016

Interventions

  • Behavioral: Speech-Repetition-Therapy
  • Behavioral: Melodic Intonation Therapy

Specialties

  • Neurology: Stroke/Vascular
  • Physician Assistant: Neurology

MeSH Terms

  • Aphasia
  • Broca
  • Stroke

Study ID

Beth Israel Deaconess Medical Center -- DC008796

Status

Unknown

Trial ID

NCT00903266

Study Type

Interventional

Trial Phase

Phase 3

Enrollment Quota

30

Sponsor

Beth Israel Deaconess Medical Center

Inclusion Criteria

    1. 21-80 years of age 2. first-time ischemic left-hemispheric stroke or cerebrovascular accident 3. at least 12 months out from first ischemic stroke 4. right-handed (prior to stroke) 5. diagnosis of non-fluent or dysfluent aphasia

Exclusion Criteria

    1. older than 80 years of age 2. more than 1 stroke 3. presence of metal or metallic or electronic devices that cannot be exposed to the MRI environment 4. a terminal medical condition history of major neurological or psychiatric diseases (e.g. epilepsy meningitis, encephalitis) 5. use of psychoactive drugs/medications such as antidepressants, antipsychotic, stimulants 6. active participation in other stroke recovery trials testing experimental interventions

Gender

Both

Ages

21 Years to 80 Years

Accepts Healthy Volunteers

No

Study Locations and Contact Information (1)

Study Location Distance Name Phone Email
Beth Israel Deaconess Medical Center Harvard Medical School - Boston, Massachusetts 2.4 miles None None None

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