Melodic-Intonation-Therapy and Speech-Repetition-Therapy for Patients With Non-fluent Aphasia


We are doing this clinical trial in order to evaluate two different treatments for non-fluent aphasia: Melodic Intonation Therapy (MIT) and Speech Repetition Therapy (SRT). MIT uses a simple form of singing, while SRT uses intensive repetition of a set of words and phrases. We want to see which intensive form of treatment is more effective in leading to an improvement in speech output compared to a no-therapy control period, and whether either treatment can cause changes in brain activity during speaking and changes in brain structure. We will use a technique known as functional Magnetic Resonance Imaging (fMRI) to measure blood flow changes in the brain and structural MRI that assess brain anatomy and connections between brain regions. We will use fMRI to assess brain activity while a patient speaks, sings, and hums. We will assess changes in brain activity and in brain structure by comparing scans done prior to treatment to scans obtained after treatment and we will also examine changes between treatment groups. We will correlate changes in brain activity and brain structure with changes in language test scores.

Study Start Date

February 2008

Estimated Completion Date

December 2016


  • Behavioral: Speech-Repetition-Therapy
  • Behavioral: Melodic Intonation Therapy


  • Neurology: Stroke/Vascular
  • Physician Assistant: Neurology

MeSH Terms

  • Aphasia
  • Broca
  • Stroke

Study ID

Beth Israel Deaconess Medical Center -- DC008796



Trial ID


Study Type


Trial Phase

Phase 3

Enrollment Quota



Beth Israel Deaconess Medical Center

Inclusion Criteria

    1. 21-80 years of age 2. first-time ischemic left-hemispheric stroke or cerebrovascular accident 3. at least 12 months out from first ischemic stroke 4. right-handed (prior to stroke) 5. diagnosis of non-fluent or dysfluent aphasia

Exclusion Criteria

    1. older than 80 years of age 2. more than 1 stroke 3. presence of metal or metallic or electronic devices that cannot be exposed to the MRI environment 4. a terminal medical condition history of major neurological or psychiatric diseases (e.g. epilepsy meningitis, encephalitis) 5. use of psychoactive drugs/medications such as antidepressants, antipsychotic, stimulants 6. active participation in other stroke recovery trials testing experimental interventions




21 Years to 80 Years

Accepts Healthy Volunteers


Study Locations and Contact Information (1)

Study Location Distance Name Phone Email
Beth Israel Deaconess Medical Center Harvard Medical School - Boston, Massachusetts 2.4 miles None None None provides clinical trial listings in an easy to view format. All clinical trial information is pulled directly from This website does not guarantee acceptance into any clinical trial, and is not responsible for adverse events that may be incurred from a clinical trial.