Serum Biomarkers to Characterize the Effects of Therapy on Ovarian Reserve in Premenopausal Women With Early-stage Breast Cancer or BRCA Mutations
The purpose of this study is to see how the cancer treatment affects the ovaries. Cancer treatment can make it hard for a person to conceive a child in the future. It may also bring on early menopause. We will check blood levels of hormones that the ovaries produce. We will do this before, during, and after the cancer treatment. We will also ask the patient to fill out questionnaires about their menstrual cycle (periods) and information about your health and pregnancies. This may help us learn which women will be more likely to have early menopause.
Study Start Date
Estimated Completion Date
- Other: Blood draw and questionaires
- Other: Blood draw and questionnaires
- Obstetrics & Gynecology: Breast,Menopausal Medicine
- Family Medicine: Women`s Health
- Oncology: Breast
- Physician Assistant: Obstetrics/Gynecology,Women`s Health
- Breast Neoplasms
Memorial Sloan-Kettering Cancer Center -- 08-156
Memorial Sloan-Kettering Cancer Center
- Premenopausal female patients age 18-44 with breast cancer as defined as: a. AJCC Stage 0-III breast cancer, regardless of hormone-receptor status or HER2-overexpression, before the start of planned adjuvant or neoadjuvant chemotherapy and/or hormonal therapy. If chemotherapy is planned, the regimen must be either CMF, anthracycline containing, or taxane containing. If hormonal therapy is planned, the regimen must be limited to tamoxifen. All biologics (e.g. bevacizumab, trastuzumab, lapatinib, etc.) are allowed in addition to the above therapies.
- ECOG performance status 0-1
- Have regular menstrual cycles patients can have no more than 1 irregular cycle (too early or too late) within the past year and/or at least 10 spontaneous cycles within the past year.
- Prior therapy for breast cancer or any other cancer, such as chemotherapy, hormonal therapy or immunotherapy.
- Ovarian resection, unilateral or bilateral oophorectomy, hysterectomy or radiation to pelvic region.
- Plans for risk-reducing bilateral oophorectomy within one year of completion of chemotherapy.
- Prior known infertility infertility is defined as one year of inability to conceive despite unprotected intercourse and/or the need to use medication (e.g clomiphene) or assisted reproductive technology (e.g. intrauterine insemination or in vitro fertilization) to attempt pregnancy.
- Family history of a first-degree relative with non-surgical menopause < age 40
- Current pregnancy.
18 Years to 44 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Study Locations and Contact Information (6)
|Memorial Sloan Kettering Cancer Center Suffolk - Commack, New York||26.2 miles||Maura Dickler MD||646-888-4560||None|
|Memorial Sloan Kettering Cancer Center Suffolk - Commack, New York||26.2 miles||None||None||None|
|Memorial Sloan Kettering Cancer Center - New York, New York||50.7 miles||None||None||None|
|New York Presbyterian HospitalWeill Medical College of Cornell University - New York, New York||50.7 miles||None||None||None|
|Memorial Sloan Kettering Cancer Center - New York, New York||50.7 miles||Maura Dickler MD||646-888-4560||None|
|New York Presbyterian HospitalWeill Medical College of Cornell University - New York, New York||50.7 miles||Tessa Cigler MD||None||None|