Changes in Insulin Sensitivity After Weight Loss


The main hypothesis of this study is that weight loss induced by gastric bypass will induce a greater improvement in insulin sensitivity compared with gastric banding or low calorie diet. Subjects will be studied before and after weight loss. Studies consist of intravenous glucose tolerance test, body composition analysis, meal test, and energy expenditure.

Study Start Date

March 2005

Estimated Completion Date

August 2016


  • Procedure: gastric bypass surgery or sleeve gastrectomy
  • Procedure: Gastric bypass
  • Behavioral: Very low calorie diet
  • Procedure: Gastric banding
  • Procedure: Sleeve gastrectomy
  • Behavioral: Liquid Diet


  • Surgery: Hernia/GI
  • Gastroenterology: Obesity,Parenteral/Ent Nutrition
  • Endocrinology: Diabetes,Obesity
  • Nurse Practitioner: Nutrition,Preventive Medicine

MeSH Terms

  • Diabetes Mellitus
  • Diabetes Mellitus, Type 2
  • Obesity
  • Weight Loss
  • sleeve gastrectomy

Study ID

Columbia University -- AAAB2401



Trial ID


Study Type


Trial Phase


Enrollment Quota



Columbia University

Inclusion Criteria

  • must have diabetes
  • adults with diabetes undergoing gastric bypass or sleeve gastrectomy (the study does not pay for the surgery)
  • obese adults with diabetes willing to undergo an inpatient weight loss diet for 2 to 3 weeks

Exclusion Criteria

  • use of triglyceride lowering medication or weight loss medication




18 Years to 75 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Study Locations and Contact Information (1)

Study Location Distance Name Phone Email
Columbia University Medical Center - New York, New York 44.8 miles Gerardo Febres MD 212-342-0281 None provides clinical trial listings in an easy to view format. All clinical trial information is pulled directly from This website does not guarantee acceptance into any clinical trial, and is not responsible for adverse events that may be incurred from a clinical trial.