Changes in Insulin Sensitivity After Weight Loss

Description

The main hypothesis of this study is that weight loss induced by gastric bypass will induce a greater improvement in insulin sensitivity compared with gastric banding or low calorie diet. Subjects will be studied before and after weight loss. Studies consist of intravenous glucose tolerance test, body composition analysis, meal test, and energy expenditure.

Study Start Date

March 2005

Estimated Completion Date

August 2016

Interventions

  • Procedure: gastric bypass surgery or sleeve gastrectomy
  • Procedure: Gastric bypass
  • Behavioral: Very low calorie diet
  • Procedure: Gastric banding
  • Procedure: Sleeve gastrectomy
  • Behavioral: Liquid Diet

Specialties

  • Surgery: Hernia/GI
  • Gastroenterology: Obesity,Parenteral/Ent Nutrition
  • Endocrinology: Diabetes,Obesity
  • Nurse Practitioner: Nutrition,Preventive Medicine

MeSH Terms

  • Diabetes Mellitus
  • Diabetes Mellitus, Type 2
  • Obesity
  • Weight Loss
  • sleeve gastrectomy

Study ID

Columbia University -- AAAB2401

Status

Unknown

Trial ID

NCT00627484

Study Type

Interventional

Trial Phase

N/A

Enrollment Quota

110

Sponsor

Columbia University

Inclusion Criteria

  • must have diabetes
  • adults with diabetes undergoing gastric bypass or sleeve gastrectomy (the study does not pay for the surgery)
  • obese adults with diabetes willing to undergo an inpatient weight loss diet for 2 to 3 weeks

Exclusion Criteria

  • use of triglyceride lowering medication or weight loss medication

Gender

Both

Ages

18 Years to 75 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Study Locations and Contact Information (1)

Study Location Distance Name Phone Email
Columbia University Medical Center - New York, New York 44.8 miles Gerardo Febres MD 212-342-0281 None

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