Using Fluorine-18-Labeled Fluoro-Misonidazole Positron Emission Tomography To Detect Hypoxia in Head and Neck Cancer Patients

Description

The purpose of this study is to evaluate low oxygen areas called hypoxia within the tumor. These low oxygen areas are thought to be the reason why tumors are more resistant to chemotherapy and radiation treatments. A recent imaging technique using a hypoxia tracer called Fluoromisonidazole (FMISO) can detect low oxygen areas within the tumor. This imaging technique, called a PET scan, uses positively charged particles to detect slight changes in the body biochemistry and metabolism. FMISO PET scans have been performed in patients with head and neck cancer and have shown the ability to detect these low oxygen areas within the tumor.

Study Start Date

June 2004

Estimated Completion Date

June 2016

Interventions

  • Device: 18F-FMISO PET scan
  • Other: F-MISO PET scan
  • Device: MRI
  • Device: FDG PET/CT scan
  • Radiation: fluorine-18-labeled fluoro-misonidazole (18F-FMISO)

Specialties

  • Oncology: Diagnostics/Radiology,Head and Neck
  • Radiology: CT/SPECT/PET,Nuclear Medicine
  • Otolaryngology: Head and Neck,Radiology/Diagnostics
  • Physician Assistant: Hematology/Oncology,Radiology

MeSH Terms

  • Anoxia
  • F-MISO PET scan
  • Head and Neck Neoplasms

Study ID

Memorial Sloan-Kettering Cancer Center -- 04-070

Status

Unknown

Trial ID

NCT00606294

Study Type

Interventional

Trial Phase

N/A

Enrollment Quota

150

Sponsor

Memorial Sloan-Kettering Cancer Center

Inclusion Criteria

  • provide written informed consent
  • histologically confirmed diagnosis of head and neck carcinoma (excluding nasopharynx, paranasal sinus, salivary, and thyroid malignancies) (2002 AJCC)
  • 18 years of age or older
  • newly diagnosed head and neck carcinoma (excluding nasopharynx, paranasal sinus, salivary, and thyroid malignancies) must not have received prior radiation therapy or chemotherapy or surgery (except for biopsy) for this diagnosis
  • Karnofsky performance status >= 70.

Exclusion Criteria

  • all nasopharyngeal, paranasal sinus, salivary cancer, and thyroid malignancies
  • Karnofsky performance status < 70
  • prior chemotherapy or radiotherapy within the last three years
  • patients that underwent surgical resection for the same disease (except for biopsy)
  • any prior radiotherapy to the head and neck region
  • pregnant (confirmed by serum b-HCG in women of reproductive age) or breast feeding

Gender

Both

Ages

18 Years and older

Accepts Healthy Volunteers

No

Study Locations and Contact Information (7)

Study Location Distance Name Phone Email
Memorial Sloan Kettering Cancer Center at Commack - Commack, New York 26.2 miles None None None
Memorial Sloan Kettering West Harrison - West Harrison, New York 28.7 miles Nancy Lee MD 212-639-3341 None
Memorial Sloan Kettering West Harrison - West Harrison, New York 28.7 miles None None None
Memorial Sloan Kettering Cancer Center at Phelps Memorial Hospital Center - Sleepy Hollow, New York 33.0 miles Nancy Lee MD 212-639-3341 None
Memorial Sloan Kettering Cancer Center at Phelps Memorial Hospital Center - Sleepy Hollow, New York 33.0 miles None None None
Memorial Sloan Kettering Cancer Center at Mercy Medical Center - Rockville Centre, New York 43.4 miles None None None
Memorial Sloan Kettering Cancer Center - New York, New York 50.7 miles None None None

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