Neurobiology of Psychogenic Movement Disorder and Non-Epileptic Seizures

Description

This study is part of a series of studies that will explore how the mind and the brain work to cause episodes of uncontrollable shaking in people who have no known underlying brain or medical disorder. The study is conducted at NIH and at the Brown University Rhode Island Hospital. Healthy volunteers and people with psychogenic movement disorders (PMD) or non-epileptic seizures (NES) who are 18 years of age or older may be eligible for this study. Patients with NES have 3 teaspoons of blood drawn. The blood is tested for two genes that are normally found in healthy individuals to see if they are found more frequently in patients with uncontrolled shaking. Patients with PMD have blood drawn for testing and also undergo functional magnetic resonance imaging (fMRI) to look at how the brain functions while the subject performs a specific task. MRI uses a strong magnetic field and radio waves to obtain images of body organs and tissues. During the scan, the subject lies on a table that can slide in and out of the scanner, a metal cylinder. The scan lasts about 60 to 90 minutes, during which the subject may be asked to lie still for up to 10 minutes at a time and to perform tasks, such as identifying the gender of faces shown on a screen. Healthy volunteers may have blood drawn for genetic testing or fMRI or both....

Study Start Date

July 2007

Estimated Completion Date

Not specified

Interventions

No interventions cited

Specialties

  • Internal Medicine: Neurology
  • Neurology: Movement Disorders,Seizure
  • Physician Assistant: Neurology

MeSH Terms

  • Movement Disorders
  • Seizures

Study ID

National Institutes of Health Clinical Center (CC) -- 070190

Status

Unknown

Trial ID

NCT00500994

Study Type

Observational

Trial Phase

N/A

Enrollment Quota

305

Sponsor

National Institutes of Health Clinical Center (CC)

  • INCLUSION CRITERIA: GENERAL INCLUSION CRITERIA FOR PMD PATIENTS:
  • Diagnosis of clinically definite PMD utilizing Fahn and Williams criteria. The diagnosis must be made by a neurologist.
  • Able to give informed consent
  • Age 18 or older GENERAL INCLUSION CRITERIA FOR NES PATIENTS:
  • Diagnosis of NES based on recording of patient's typical episode during 24 hour video-EEG without concomitant EEG changes. The diagnosis must be made by a neurologist.
  • Able to give informed consent
  • Age 18 or older INCLUSION CRITERIA FOR HEALTHY VOLUNTEERS:
  • Able to give informed consent
  • Age 18 or older GENERAL EXCLUSION CRITERIA FOR PMD PATIENTS:
  • Significant neurological disorders (primary or comorbid) such as neurodegenerative disorders, stroke, movement disorders or epilepsy
  • Inflammatory disorders or autoimmune disorders active within the last 6 months
  • Patients with psychotic disorders or manic depression or active substance abuse within the last 6 months
  • Current suicidal ideation
  • Disease severity requiring inpatient treatment ADDITIONAL EXCLUSION CRITERIA FOR PMD PATIENTS FOR fMRI:
  • Patients with movement symptoms at rest
  • Previous history of or MRI findings consistent with brain tumors, strokes, trauma or arterial venous malformations
  • History of traumatic brain injury with loss of consciousness or amnesia lasting greater than a few seconds
  • Contraindication to MRI
  • Pregnancy
  • Significant medical illness
  • Patients with current post-traumatic stress disorder, panic disorder or obsessive compulsive disorder
  • Patients on antidepressants or antiepileptic medications 2 weeks prior to testing GENERAL EXCLUSION CRITERIA FOR NES PATIENTS:
  • Significant neurological disorders (primary or comorbid) such as neurodegenerative disorders, stroke, movement disorders or epilepsy
  • Inflammatory disorders or autoimmune disorders active within the last 6 months
  • Patients with psychotic disorders or active substance abuse within the last 6 months
  • Current suicidal ideation
  • Disease severity requiring inpatient treatment EXCLUSION CRITERIA FOR HEALTHY VOLUNTEERS FOR fMRI:
  • Previous history of or MRI findings consistent with brain tumors, strokes, trauma or arterial venous malformations
  • Contraindication to MRI
  • Pregnancy
  • Significant medical illness
  • History of DSM IV-defined schizophrenia, schizoaffective disorder, bipolar disorder or major depression with psychosis
  • Subjects with post-traumatic stress disorder, obsessive compulsive disorder or panic disorder
  • Subjects on antidepressants or antiepileptic medications
  • Gender

    Both

    Ages

    18 Years to 90 Years

    Accepts Healthy Volunteers

    Accepts Healthy Volunteers

    Study Locations and Contact Information (3)

    Study Location Distance Name Phone Email
    Brown University Rhode Island Hospital - Providence, Rhode Island 41.0 miles None None None
    Brown University Rhode Island Hospital - Providence, Rhode Island 41.0 miles None None None
    National Institutes of Health Clinical Center 9000 Rockville Pike - Bethesda, Maryland 391.1 miles None None None

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