Real-Time Image Guided Lymphatic Mapping and Nodal Targeting in Lung Cancer


The primary purpose of this study is to determine if we can identify the first lymph node that drains from the tumor, and thus would be the most likely site for metastatic disease, and remove it for analysis to improve the ability to detect tumor in this node and to remove this additional site that potentially contains tumor cells.

Study Start Date

January 2009

Estimated Completion Date

January 2019


  • Procedure: Near Infrared Imaging


  • Internal Medicine: Hematology/Oncology,Pulmonology
  • Nursing: Hematology/Oncology,Pulmonology
  • Pulmonology: Lung/Thoracic Oncology
  • Oncology: Lung/Thoracic Oncology

MeSH Terms

  • Lung Neoplasms

Study ID

Dana-Farber Cancer Institute -- 05-219



Trial ID


Study Type


Trial Phase

Phase 1

Enrollment Quota



Dana-Farber Cancer Institute

Inclusion Criteria

  • Suspected or histologically documented new non-small cell carcinoma that have agreed to undergo a thoracotomy for segmentectomy, lobectomy, bilobectomy or pneumonectomy as recommended by their thoracic surgeon for treatment
  • Surgically resectable lung cancer
  • N2 lymph nodes negative on PET scan or mediastinoscopy
  • Age > or equal to 18 years of age
  • Men, women of non-child bearing age or women with a negative pregnancy test

Exclusion Criteria

  • Patient does not want to undergo subsequent surgical resection
  • Medical condition such as uncontrolled infection or cardiac disease that, i the opinion of the treating surgeon, makes resection unreasonably hazardous for the patient.
  • T4 or N2 disease
  • Pre-operative spirometry that suggests they cannot undergo resection of their primary tumor by segmentectomy, lobectomy, bilobectomy, or pneumonectomy
  • Iodide or seafood allergy
  • Pregnant or lactating women




18 Years and older

Accepts Healthy Volunteers


Study Locations and Contact Information (3)

Study Location Distance Name Phone Email
DanaFarber Cancer Institute - Boston, Massachusetts 2.6 miles None None None
Brigham and Womens Hospital - Boston, Massachusetts 2.6 miles None None None
Beth Israel Deaconess Medical Center - Boston, Massachusetts 2.6 miles None None None provides clinical trial listings in an easy to view format. All clinical trial information is pulled directly from This website does not guarantee acceptance into any clinical trial, and is not responsible for adverse events that may be incurred from a clinical trial.