Intrinsic Optical Imaging Study to Map Neocortical Seizure in Human Epilepsy Patients

Description

Epilepsy is a disease affecting 1-2% of the population. Currently, the only known cure for epilepsy is surgery, which is much more effective at eliminating seizures arising from the medial temporal lobe compared with the neocortex. The problem with neocortical epilepsy is that the population of neurons underlying each epileptiform discharge varies over time. In addition, the spatial relationship between interictal events and the ictal onset zones, which are critical in defining the region of epileptogenesis, is not well understood and essential to the surgical treatment of epilepsy. Electrophysiological recording methods, although currently the "gold standard" in mapping epilepsy, are inadequate to address these questions based on restrictions due to volume conduction or sampling limitations. Optical recording techniques can overcome many of these limitations by sampling large areas of cortex simultaneously to provide information about blood flow, metabolism and extracellular fluid shifts that are intimately related to excitatory and inhibitory neuronal activity. In fact, optical recordings may actually be more sensitive to certain aspects of epileptic activity than electrophysiologic recordings. The goal will be to translate these findings into the operating room and map human neocortical epilepsy with the same optical techniques. Outcome following surgical resections to treat neocortical epilepsy will be correlated with the optical maps to determine the utility of intrinsic signal imaging in guiding brain surgery. These experiments will set the groundwork for implementing optical recordings in general clinical practice as a novel technique for mapping and predicting human seizures.

Study Start Date

May 2002

Estimated Completion Date

December 2018

Interventions

No interventions cited

Specialties

  • Neurology: Seizure
  • Radiology: Neuroradiology
  • Physician Assistant: Neurology,Radiology

MeSH Terms

  • Epilepsy
  • Seizure

Study ID

Weill Medical College of Cornell University -- 0102004808

Status

Unknown

Trial ID

NCT00195052

Study Type

Observational

Trial Phase

N/A

Enrollment Quota

40

Sponsor

Weill Medical College of Cornell University

Inclusion Criteria

  • patients with medically intractable epilepsy, between 18-65 ages

Exclusion Criteria

    -

Gender

Both

Ages

18 Years to 65 Years

Accepts Healthy Volunteers

No

Study Locations and Contact Information (2)

Study Location Distance Name Phone Email
Weill Cornell Medical CollegeNew York Presbyterian Hospital - New York, New York 48.5 miles None None None
Weill Cornell Medical CollegeNew York Presbyterian Hospital - New York, New York 48.5 miles None None None

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