Promote a Clinical Trial

A Pilot Study of Deep Brain Stimulation to the Lateral Habenulae in Treatment-Resistant Depression

This research proposal will investigate the safety, tolerability, and efficacy of bilateral deep brain stimulation (DBS) to the lateral habenula for patients with highly treatment-resistant major depressive disorder (TRD). Six adult patients with TRD will be recruited for this single-site study at Mount Sinai Medical Center; patients will be chronically symptomatic with significant functional disability, and have demonstrated resistance to standard somatic and psychotherapeutic treatments. The primary outcome measure will be the change in the 17-item Hamilton Depression Rating Scale (HDRS17) 6 months after the commencement of stimulation.

Sponsored by: Mount Sinai School of Medicine