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Immunotoxin Therapy and Cytarabine in Treating Patients With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia

This study will test different doses of combotox to find out what dose of this drug can be given safely to patients. Combotox will be given with cytarabine. Patients might have been given cytarabine as part of their treatment for ALL before; even if they have received cytarabine before, it usually still works when it is given if the leukemia has not completely disappeared with the first treatment (or is "refractory") or if the leukemia has come back (or has "relapsed"). Another purpose of this study is to find out what effects (good and bad) the experimental drug Combotox has on the patient and patient`s disease (ALL) when combined with cytarabine.

Sponsored by: Montefiore Medical Center