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The Genetics of Severe Asthma in Children

Near fatal asthma exacerbations are one of the most common causes of critical illness in children, accounting for approximately ten thousand intensive care unit (ICU) admissions per year in the United States. Even children with intermittent or mild baseline asthma can develop these severe exacerbations; however, there are few studies evaluating the risk factors associated with the development of near fatal asthma exacerbations in children. Inhaled ß2-adrenergic receptor (ADRß2) agonist therapy is the foundation of therapy for acute asthma and genetic variations of this receptor have been shown to affect response to ADRß2 agonist therapy in this population. The investigators hypothesis is that a child's ADRß2 genotype is associated with the development of a near fatal asthma exacerbation.

Sponsored by: Connecticut Children's Medical Center